Synthetic Approaches Towards Biologically Active Heterocycles Employing Catalytic Strategies

Abstract

The present thesis work conceptualizes the application of catalytic protocols towards synthesis of biologically active heterocycles. The heterocycles have been a prime point of attraction for synthetic chemists due to their impressive structural inlay and also enormous pharmaceutical properties. In one part of the work, we have described metal free synthesis of 2-methylene-selanyl-4-chromanols, indanols, chromans and 7-membered oxa-cycle employing TMSOI and TFA in catalytic amounts. In the other part, we have discussed the transition metal catalysed stereoselective synthesis of dihydrofurans, furans and 2-methylene-4-chromanols using Au(III) and Cu(I) catalyst in ‘‘open-air’’ reaction condition.