Role of DNMT in cancer

Abstract

DNA methylation is a biochemical process catalyzed by enzyme DNA Methyltransferases (DNMTs). In most of the carcinogenesis DNMTs are over expressed and aberrant genomic DNA methylation pattern (genome wide hypomethylation and regional hypermethylation) are being observed. One of such consequences results in hypermethylation of Tumor Suppressor Genes. In different cancerous, different DNMTs show significantly elevated expression than their normal cells. In our study we have investigated relative expression of DNMTs and TSGs in normal and cancerous tissue. We found that DNMT3A expression level is comparatively more than the other DNMTs and it may cause the transcriptional repression of TSGs, particularly in lymph Node cancer.
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