Cobalt(II) and Nickel(II) Complexes of Aroyl Hydrazone Ligand: Synthesis and Characterization

Abstract

Abstract
The remarkable biological activity of acid hydrazides R–CO–NH–NH2, their corresponding aryolhydrazones R–CO–NH–N=CHR, and also their mode of chelation with transition metal ions has aroused interest in the past due to possible biomimetic applications. Hydrazone Schiff bases and their Cobalt and Nickel complexes have a variety of applications in biological, clinical and analytical fields. Recently there has been a considerable interest in the coordination chemistry of transition metals especially, Cobalt and Nickel with O-N donor hydrazone ligands because of their potential biological and pharmacological applications. The coordination compounds of aroylhydrazones have been reported to act as enzyme inhibitors and are useful due to their pharmacological applications.
From last one year I have been studying the chemistry of transition metal complexes with O-N containing donor environments. In this dissertation I report the synthesis and full characterization of several O-N donor Schiff’s base hydrazone ligands and their corresponding cobalt complexes. The single crystal x-ray studies of synthesized Co complexes (1-3) are under process with our collaborator. One of the three synthesized Co compound (complex 2) is successfully characterized by X-ray crystallography. But due to incomplete refinement of x-ray date I am unable to show the x-ray structure in this dissertation. I also report the synthesis of some Nickel complexes of corresponding O-N donor hydrazone ligands but due to shortage of time am unable to present the characterization data in this thesis.
Key words: Hydrazone Lgand; O-N donor systems; Cobalt complexes; Nickel Complexes