Role of DNA methyltransferase 3A and 3B, in Human Cancer

Abstract

DNA Methylation acts as an essential regulatory mechanism of transcription affecting chromatin structure, which is established and maintained by the co-ordinate action of three DNA methyltransferases: DNMT1, DNMT3A and DNMT3B and histone modifications. Recent studies show that epigenetic change plays a major role in silencing a variety of methylated tissue-specific and imprints genes in many cancer types. Lymph node cancer is considered to result in part from the accumulation of multiple genetic alterations and leading to oncogene over expression and loss of function of tumor suppressor. The aim of this study was to check the expression of DNMT3A and DNMT3B in both normal and cancer cell. Both DNMT3A and DNMT3B shows over expression in cancer cell indicating their involvement in lymph node cancer.