Development of iontophoretic delivery system

Abstract

The current study deals with the development of a low-cost iontophoretic delivery system. Iontophoresis deals with the administration of the drug under the influence of electrical potential. A low-cost portable and user friendly pulsed iontophoretic system was developed. The efficiency
of the system, at various duty cycles, was analysed against the salicylic acid (SA)-loaded gelatin gels. The current density for the studies was maintained at 0.5 mA/cm2. The results indicated that as the duty cycle was increased there was a subsequent increase in the drug release from the
gelatin gels. 100 % duty cycle provided the best release behaviour in terms of % SA release. Taking this as the reference duty cycle, the SA release from the alginate-gelatin and chitosangelatin gels were also studied. The results indicated that as the proportion of alginate was
increased in the alginate-gelatin gels, there was an increase in the % release whereas there was a decrease in the SA release as the chitosan proportion was increased in the chitosan-gelatin gels. The release patterns indicated that the release from the gels followed Higuchian kinetics.