Numerical modelling of photodynamic therapy

Baby Kumar, Vishnu (2011) Numerical modelling of photodynamic therapy. BTech thesis.

PDF (B.Tech Dissertation)


Photodynamic Therapy (PDT) is a new and minimally invasive cancer treatment modality based on the photo-activation of a light-sensitive drug ‘Photosensitiser’ (PS). PS can be administered in various forms (e.g. as injection or ointment) and accumulates selectively in the target tumour tissue. This activated drug in turn generates singlet oxygen (1O2) in the malignant tissue and induces tissue necrosis or apoptosis. In this thesis, we have implemented a simulation model utilising the primary processes that the photosensitiser undergoes in the presence of irradiating light and molecular oxygen (3O2). We have used spectroscopic data of the commercially available and clinically significant photosensitiser ‘Photofrin®’ (porfimer sodium, Axcan Pharma, Montreal, Canada, a heterogeneous mixture of porphyrins). This model encourages predictive statements to be made regarding the efficiency of photodynamic modalities at various initial conditions, including PS concentration and tissue oxygen concentration.

Item Type:Thesis (BTech)
Uncontrolled Keywords:modelling,photodynamic therapy,photosensitiser,reactive oxygen species,lasers
Subjects:Engineering and Technology > Biomedical Engineering
Divisions: Engineering and Technology > Department of Biotechnology and Medical Engineering
ID Code:2565
Deposited By:Mr Vishnu Baby Kumar
Deposited On:17 May 2011 15:47
Last Modified:20 Dec 2013 14:32
Supervisor(s):Kumar, A

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