Preparation And Characterization Of Novel Span 80: Tween-80 Based Organogels For Food And Pharmaceutical Industries

Abstract

Tween 80-span 80 based organogels were prepared by fluid-filled structure mechanism by varying the composition of the organogels. The microstructures of the organogels were studied by light microscopy. The organogels were subjected to the accelerated stability test and time dependent stability test. The stable organogels were characterized by XRD, FTIR, and simultaneous DTA-TGA, pH and dc impedance measuring devices. Salicylic acid (model drug) was incorporated within the organogels and its release properties from the organogel matrices were studied. The antimicrobial efficiency of the salicylic loaded product was tested against Bacillus subtilis. The organogels were analyzed for biocompatibility using hemolysis studies. The microscopic studies indicated fluid-filled globular structures forming the gelled structures. The stability and the properties were found to be dependent on the proportion of the surfactant mixture (SM) and water. In general, when the ratio of SM: water was in the range of 1.3-1.6, the samples showed higher stability and improved properties. The release of SA from the organogels was found be combination of Fickian and non-Fickian kinetics. The samples showed good antimicrobial study and were found to be biocompatible in nature.