Synthesis of o-aryloxime

Abstract

An efficient CuI catalyst for the O-arylation of Benzaldoxime with aryl iodide has been developed.Here Benzaldooxime serves as an efficient for C-O cross-coupling thereby allowing for the preparation of O-aryloxime from simple aryl halide.This is a single step synthesis Short reaction times and broad substrate scope, including heteroaryl coupling partners, allow access to O-aryloximes that would be difficult to prepare in a single step by
traditional methods. This one-step formation of the dN-O-Ar linkage givesaccess to a range of oxime ethers in good to moderate yields.