Expression of HDAC1 in leukemia cells

Abstract

Histone deacetylases (HDACs) is an enzyme which removes the acetyl group and thus completes the reversible modification of histone by acetylation. DNA in a chromatin is very tightly associated with proteins called histones, which packages in nucleosomes also found in chromatin are many nono histones proteins, some of which help maintain chromosomes structures and others that regulate the expression of specific genes. Histones are found in all eukaryotic cells having molecular weights between 11,000 and 21,000. They are rich in amino acids like arginine and lysine. Histones are subjected to enzymatic modification like methylation, acetylation, ADP-ribosylation, phosphorylation, ubiquitination. Histone acetylation and deacetylation are two regulatory and opposing mechanism in leukemia cells. HDACs are major groups for causing repression of tumour suppressor genes and hence they cause cancer. So HDACs can be a proved a promising target for curing cancer.