Dietary bioactive compounds as histone deacetylase inhibitor for cancer prevention

Abstract

Cancer is major disease causing worldwide human death which is related to different epigenetic dysregulation. One of the major dysregulation is overexpression of histone deacetylase (HDAC) including, HDAC1, HDAC4, HDAC6 and HDAC7. HDAC upregulation leads to histone deacetylation at the promoter region of tumor suppressor genes and promote histone 3 lysine 9 methylation helping in heterochromatinization, leading to abnormal changes in chromatin pattern followed by tumorigenesis. In this project novel HDAC inhibitor finding will focus a new light on cancer therapy. Our normal diet of fruits and vegetables, contain different bioactive compounds like sulforephine, allyl disulfite and butyrate, which have anti-cancerous property. Insilco study illustrate that these bioactive compound inhibit HDAC 4, 7 and 6 by binding with the active site of HDAC enzyme. This HDAC-bioactive compound complex become inactive and fails to remove acetyl group from histone tail which helps in cancer inhibition. Further experimental research will confirm the evidence of these novel inhibitors.