Impact of p53 and β1 integrin expression in leukemia cells

Abstract

p53 acts as the single most vital gene in cancer as a single mutation that can lead to tumorgenesis. p53 function has been further diversified by the discovery of various isoforms of p53. p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that is encoded by the TP53 gene in case of humans. p53 is very vital in multicellular organisms, where it maintains the cell cycle and thus act as a tumor suppressor that is associated in suppressing cancer. p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Integrin-associated signalling is a critical in signalling network in mammalian cells. Several molecules are concerned in this signalling network like the RTK, Ras, Src-family kinase, Notch, Wnt, and Raft/caveolae-mediated signalling pathways are associated to integrin signalling. Integrin signalling is also related with direct involvement of tumor formation, angiogenesis, metastasis, lipid rafts and attachment to distant tissues are largely coupled with integrin signalling. Recent data has indicated that integrin expression and its functions are tightly synchronized by epigenetic mechanisms. Alterations in these epigenetic regulation patterns are regularly associated with the development of various diseases, including cancer. Here we are trying to correlate the impact of p53 & β1 integrin in leukemia cell.