Preparation and characterization of PLA and PLGA scaffold and film

Abstract

In this research, the PLA/PLGA scaffolds and films were prepared successfully from PLA/PLGA blank microparticles. The morphology of the PLA/PLGA scaffolds and films are characterized by means of SEM. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed for cell proliferation, migration, and differentiation, and guidance for cellular in-growth. Biodegradable porous scaffolds can be surface engineered to provide an optical microenvironment for better cell adhesion and tissue in-growth. According to scanning electron microscopy (SEM), a 3-dimensional porous structure of films could be observed on the surface. As the morphology of PLA/PLGA scaffolds and films could not be stabilized, we investigated the effect of temperature and concentration of polymer on the properties of microporous scaffolds and films. The degradation of polymeric porous films occurs through a homogeneous hydrolytic chain cleavage mechanism and this process is altered by factors such as molecular weight and molecular weight distribution. So, the biocompatible film plays an important role in development of fully biodegradable, tissue compatible active wound dressing material.