Design of a perfusion bioreactor for simulating synovial joint cavity

Praharaj, Amrit (2012) Design of a perfusion bioreactor for simulating synovial joint cavity. BTech thesis.



Enthesis is the point of attachment between the bone with a tendon or a ligament. It seems more assuring to use a tissue engineered graft that is installed with fibro cartilage which is regenerated by the help of stem cells differentiation than to use a ligament alone graft to replace an injured ligament. Hence a bioreactor system is necessary to mimic this concept and environment of enthesis. A bioreactor system is planned that can be used to conduct perfusion of a cell seeded scaffold for a ligament graft with a medium similar to synovial fluid composition. Various parameters like pressure, temperature, oxygen, carbon dioxide, PH etc. in the bioreactor can be controlled and regulated to simulate the in-vivo conditions. The bioreactor could also provide a two dimensional movement that would impart a compressional and tensile force to the scaffold for development of enthesis. Thus it would mimic the in vivo conditions of a joint cavity and simulate the environmental condition which is necessary for the development of enthesis

Item Type:Thesis (BTech)
Uncontrolled Keywords: bioreactor, enthesis, scaffold,movement
Subjects:Engineering and Technology > Biomedical Engineering
Divisions: Engineering and Technology > Department of Biotechnology and Medical Engineering
ID Code:3590
Deposited By:Mr. Amrit Praharaj
Deposited On:28 May 2012 16:20
Last Modified:28 May 2012 16:20
Supervisor(s):Nayak, B P

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