Development and charecterization of soy lecithin and palm oil based organogels

Abstract

Preparation and characterization of soy lecithin (SL) and palm oil (PO) based organogels have been reported in this study. The optimization of the composition of the organogels was carried out by varying the proportions of SL, PO and water. Microscopic studies suggested the presence of aqueous phase either as fluid filled fibers or spherical droplets or both, depending on the composition of the organogels. FTIR study indicated strong intermolecular hydrogen bonding amongst the organogel components. The pHs of the organogels was found to be ~ 5.75 and were hemocompatible. The release of metronidazole (MZ; model drug) suggested diffusion mediated drug release. MZ loaded organogels have shown good antimicrobial property against B. subtilis and E. coli.