Elucidation of the anticancer property of Abrus agglutinin in oral cancer cell lines

Abstract

Abrus agglutinin, a ribosome inhibiting protein II (RIP II) family lectin, is a heterotetrameric glycoprotein of molecular weight 134 kDa which is composed of two A chains (N-glycosidase activity on 60S eukaryotic ribosome) and two B chains (galactose binding site) linked through a disulphide bridge. Here we studied the anti cancer activity of Abrus agglutinin in various oral cancer cell lines. The protein synthesis inhibitory activity of Abrus agglutinin (IC50) in various oral cell lines is 7.5 µg, 6 µg , 1.25 µg, 56.66 µg in HEp2, RPMI-2650, FaDu, HaCaT respectively. The study confirmed Abrus agglutinin acts as a magic bullet for combating oral cancer .