In silico structure prediction of γ-secretase: a key enzyme in Alzheimer’s disease

Abstract

Alzheimer’s disease is one of the most common forms of neurodegenerative disease in which the extracellular deposition of fibrils and tangles of the aggregation of amorphous amyloid â-peptide are found in some part of the brain, mainly in the region responsible for learning,memory and emotional behavior. Neurons that use glutamate and acetylcholine as neurotransmitter are mainly affected. The disease is caused due to the deposition of Aâ amyloid extracellular. The protein AAP is break down into Aâ amyloid fragments by ã-secretase and á-secretase enzyme that in later stage forms aggregate. Although á- secretase has its chemical structure but ã-secretase which has four subs unit structure has yet not been found. Here we will try to predict the structure of these subunits though Ab Initio structure prediction method. And using the subunit structure we will try to predict complex structure.