Concanavalin A induced autophagy switches to apoptosis

Panda, Madhusmita (2014) Concanavalin A induced autophagy switches to apoptosis. MSc thesis.



Concanavalin A (Con A) is a lectin or carbohydrate binding protein having broad range of significant biological functions such as anti-tumor, anti-viral,anti-inflammatory, anti-proliferative activities. The current study intends to focus on the role of Con A in cell death mechanisms autophagy and apoptosis in oral cancer cell line Hep-2. The acridine orange staining demonstrates that Con A is able to induce oral cancer cell autophgy. The ability of con A to induce apoptosis was studied using various staining procedure such as DAPI, Annexin V-FITC staining and Caspase-3/7 Glo assay. Additionally how chloroquine possesses the potential to inhibit the autophgic activity of con A has also been studied. As conclusion, the molecular mechanism of Con A induced cell death by autophagy followed to apoptosis in oral cancer has been well discussed, which will lead to opening of new perspectives for Con A as potential anti-cancer drugs in future oral cancer therapeutics.

Item Type:Thesis ( MSc)
Uncontrolled Keywords:Lectin,Con A,Cancer,Apoptosis,Autophagy
Subjects:Life Science > Cancer Biology
Divisions: Sciences > Department of Life Science
ID Code:5774
Deposited By:Hemanta Biswal
Deposited On:01 Aug 2014 16:21
Last Modified:01 Aug 2014 16:21
Supervisor(s):Bhutia, S K

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