Mohapatra, S (2014) Therapeutic potentials of black tea medicaments. BTech thesis.
Tea; a product of Camellia Sinensis plant is the most broadly used beverage in the world. Tea phytochemicals have been studied for the prevention of various chronic diseases, such as cancer, obesity, diabetes, jaundice, hypertension and inflammation related disorders. Whereas many studies have revealed the potential efficiency of tea for the prevention of these physiological disorders, the underlying mechanisms remain unclear. In this work, we evaluated the evidence and discussed the significance of proposed mechanisms for the prevention of the diseases such as Alzheimer’s, obesity, diabetes mellitus type II, hypertension and asthma by tea. Molecular docking method was used to explore the ability of tea phytochemicals to inhibit the key enzymes. The three dimensional structure of target enzymes were either retrieved from protein data bank or modelled using swiss model. Autodock4.2 software was used for molecular docking that applies Lamarckian Genetic Algorithm. The ligand structures were retrieved from PubChem and KNApSAcK-3D database. PreADMET web server was used for Toxicity and ADME predictions. Based on this analysis, it has been found that theaflavin, rutin and 8-c-ascorbyl epigallocatechin could be the potential lead molecules as they act as inhibitor for most of the target enzymes and has a good drug score and also qualifies the toxicity and ADME test. Further the tea extract is loaded in liposomal drug delivery system and pectin-HEMA hydrogel system to analyse their drug delivery potential and it was found that liposomal system is best suitable for delivery to brain and hydrogel system better serve as colon specific delivery system. We concluded that these phytochemicals or their derivatives can be used for further in-vitro and in-vivo studies to produce valuable lead drug candidates.
|Item Type:||Thesis (BTech)|
|Uncontrolled Keywords:||Phytochemicals, Molecular Docking, ADME & TOX, liposomal encapsulation, hydrogel|
|Subjects:||Engineering and Technology > Biomedical Engineering|
|Divisions:||Engineering and Technology > Department of Biotechnology and Medical Engineering|
|Deposited By:||Hemanta Biswal|
|Deposited On:||11 Aug 2014 11:54|
|Last Modified:||11 Aug 2014 11:54|
|Supervisor(s):||Ray, S S|
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