Development of gelatin based hydrogel,emulsion hydrogel,bigel :- a comparative study

Abstract

The present manuscript has been designed to study the physicochemical and electrical properties of the gelatin based hydrogel, emulgel and bigel. The chemical studies suggested an increase in the hydrogen bonding in the emulgel and bigel when sesame oil (representative vegetable oil) and sesame oil organogel (representative organogel) were incorporated within the gelatin matrix. Emulgel and bigel showed better mechanical properties and higher electrical impedances as compared to the hydrogel. Hydrogel showed similar swelling at pH 1.2 and pH 7.2. The swelling of the emulgel and bigel was higher in pH 7.2. The formulations were found to be highly hemocompatible indicating their biocompatible nature. Ciprofloxacin, a model antimicrobial drug, was incorporated within the formulations. The release of the drug was found to be diffusion mediated. The antimicrobial efficiency of all the drug loaded formulations was found to be equivalent.