Development of low Cost Portable Platform for Bioimpedance Based Diagnostics

Abstract

Analyzing the impedance of biological samples has gained importance in the last decade. Presently all the bioimpedance analyzer available in the market are heavy and costly. In this context, an attempt has been made to develop a portable, low cost bioimpedance analyzer. For this purpose, the portable cartridges for sample analysis were prepared on cupper print circuit board by chemical etching. The developed device was successfully operated in a frequency range of 50 Hz to 20 KHz to measure impedance of various samples such as glucose, NaCl solution, bacterial cell culture and xanthan gum. All the measured samples were shown capacitive dominance. Optimization of electrode spacing and area was done to improve its efficacy in measuring the bioimpedance. Furthermore, the device was also employed for screening of anticancer drugs like cis-platin using HT-29 colon cancer cell line. The device was found operational for analyzing small sample volume (50-200ìl) , moreover portability of this developed device makes it a special among commercially available instruments used for measuring bioimpedance.