Exploring potential drugs against Scrapie disease and Creutzfeldt-Jakob disease using molecular docking techniques

Abstract

Scrapie is a lethal, degenerative sickness that influences the sensory systems of sheep and goats. Creutzfeldt-Jakob infection is a degenerative neurological issue that is serious and constantly lethal in human. Both the maladies are brought about by a protein called prion. The transformation of the á-helical, cell isoform of the prion protein (Prpc) to the insoluble, â-sheet rich irresistible, infection creating isoform (PrPsc) is the key occasion in prion illness. I have discovered two prion proteins on which the inhibitors could be docked. They are 1XYU (sheep) and 1FO7(human). I have additionally searched for different inhibitors which might be utilized to tie with the dynamic locales of the two proteins. Some of them are tannin, quinacrine, astemizole, terfenadine, lovastatin, amantadine, acyclovir, clonazepam, pentosan polysulfate, perk inhibitors, rivastigmine,etc.