Preparation and Characterization of Gelatin-Stavudine Conjugated Liposomal Nanoparticles for Better Delivery in Case Of HIV

Abstract

Nanotechnologies are gaining in commercial application. Nanoscale materials are currently being used in electronic, magnetic and optoelectronic, biomedical, pharmaceutical, cosmetic, energy, catalytic and materials applications. Nano particles as defined are particulate dispersions or solid particles with a size in the range of 10-1000nm. Gelatin based nanoparticle are prepared because of its biocompatibility and biodegradability. Gelatin nanoparticles are a delivery vehicle that could be used to deliver many therapeutics to the brain, they will be most effective in delivering drugs that cannot cross the bloodbrain barrier. In addition, they can be used for drugs of high-toxicity or a short half-life. Liposomes are mostly used for drug delivery to the targeted gene. Liposomes increases the effective action, availability, absorption of entrapped dietary and nutritional supplements which can be used as topical drug delivery system. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. The drug we use here is Stavudine, which inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA replication by incorporating into the DNA strand. The drug is dissolved, entrapped, encapsulated or attached to a nanoparticle matrix depending upon the method of preparation. The drug Stavudine conjugated with liposomes and gelatin NPs can improve the longevity of the HIV patient,leading to a better life.