Preparation and Characterization of interpenetrating Hydrogel of Hydroxyethyl Methacrylate and Methyl Cellulose

Abstract

This thesis work is aims to give an overview of preparation and characterization of Interpenetrating hydrogels of hydroxyethyl methacrylate with methyl cellulose. Interpenetrating hydrogels were prepared by cross-linking the hydroxyethyl methacrylate and methyl cellulose in the presence of different concentration of ammoniumpersulphate and tetramethylethylenediamine. The concentrations of APS 20% (w/v), 40% (w/v) whereas the concentrations of tetramethylethylenediamine were 40% (v/v), 60% (v/v). The methyl Cellulose and hydroxyethyl methacrylate were mixed in the proportion of 30:70 (w/w), 20:80(w/w), and 10:90 (w/w) before being cross-linked using ammonium persulfate and tetramethylethylenediamine. At lower portion of Methyl cellulose hydrogels were oil type formulation. The hydrogels were characterized by swelling tests at pH 7, pH 1.2 and pH 7.4 and at temp 4ºc, where the swelling at pH 7 given the best result. Physical properties were characterized by XRD, FTIR and Mechanical study. In-vitro cytotoxicity was analyzed by Biocompatibility Test. The hydrogels were found to be biocompatible in nature