Ricinus Agglutinin Induced Autophagy in Glioblastoma Cells

Sahoo, puja (2015) Ricinus Agglutinin Induced Autophagy in Glioblastoma Cells. MSc thesis.



Ricinus agglutinin (RA) is a heterodimer consisting of two chains known as chain A and chain B respectively. The molecular weight of RA is 120 kD. RA is highly toxic to normal cells due to its ability to bind to the carbohydrate moieties present on the cell surface and causes the agglutination of the erythrocytes. Toxicity of ricin is due to its catalytic activity on eukaryotic ribosomes. RA is also known as type II Ribosome Inhibiting Protein (Type II RIP).The purpose of our study was to see whether RA induces autophagic cell death or not .There were amazing results that proved that RA showed both antiproliferative activity and autophagic cell death when treated with Glioblastoma cells. Hence, RA could be effective in the treatment of Glioblastoma.

Item Type:Thesis ( MSc)
Uncontrolled Keywords:Ricinus agglutinin, type II RIP, toxic,autophagy
Subjects:Life Science > Cancer Biology
Divisions: Sciences > Department of Life Science
ID Code:6986
Deposited By:Mr. Sanat Kumar Behera
Deposited On:29 Jan 2016 16:08
Last Modified:29 Jan 2016 16:08
Supervisor(s):Bhutia, S K

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