Role of Calcimycin in Regulation of Autophagy in THP-1 Cells

Muni, Uttam Chetan (2015) Role of Calcimycin in Regulation of Autophagy in THP-1 Cells. MSc thesis.



Mycobacterium tuberculosis (M. tb), is the known pathogen for causing tuberculosis. It infects approximately one­ third of the world’s population. According to the global tuberculosis report 2013 by WHO, Tuberculosis remains a major global health problem. In 2012, nearly about 8.6 million people developed TB & 1.3 million people died from the disease. This bug enters our body through the respiratory tract and macrophages are the first phagocytes to engulf it through phagocytosis leading to the formation of phagosome. Despite various efficient host immune barriers, the bug has a tremendous ability to circumvent these barriers like inhibition of phagosome­lysosome fusion and autophagy for its intracellular multiplication and survival. Autophagy is a host defense mechanism and various published reports have shown that calcium signaling in autophagy play an important role in curtailing the disease load. So the present study is to see the regulation of autophagy in human monocytic cell line, THP­1 by Calcimycin, an important calcium ionophore that helps to increases the intracellular calcium level inside the cell

Item Type:Thesis ( MSc)
Uncontrolled Keywords:calcimycin, autophagy, THP-1, Mycobacterium tuberculosis,tuberculosis
Subjects:Life Science > Immunology
Divisions: Sciences > Department of Life Science
ID Code:6990
Deposited By:Mr. Sanat Kumar Behera
Deposited On:29 Jan 2016 15:06
Last Modified:29 Jan 2016 15:06
Supervisor(s):Dhiman, R

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