Elucidation of Anticancer Activity of Andrographis Paniculata and Its Role in the Expression of E-Cadherin and P53 in Prostate Cancer

Abstract

Plant-derived compounds act as a prevention within the development of many anti-cancer agents. Natural drugs have less toxicity than the commercially available drugs. So now a days they are widely used for curing many diseases including cancer. Among cancer especially prostrate cancer has been responsible for drastic mortality rate in males. Cancer is mainly studied by genetics and epigenetic modification. Mostly drugs are used to restore the function of tumor supressor genes..In our study, we have carried out an effort towards checking the effect of Kalmegh extracts towards restoring the expression of tumor suppressor gene, E-cadherin (CDH1) and p-53 in PC-3 cell line. HDACs are the epigenetic manipulators which plays an important role in the gene silencing which leads to the initiation of cancer and rapid proliferation.. There are several commercially available HDAC inhibitors but they are highly toxic in nature. So, here we are using the natural drugs from phytochemicals to reduce the toxicity level. As in cancer cells the tumor suppressor genes E-cadherin and P-53 shows the down regulation but while treating with the leaf extract of Andrographis paniculata the genes show up-regulation.