Combinatorial Impact OF SNPS & microRNAs in the Aetiology of Ovarian Cancer

Abstract

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation known to be associated with many cancer types including ovarian cancer, which is one of the leading causes of morbidity and mortality among women. Our present approach is focused on investigating the impact of SNPs residing within 3’UTR s of genes associated with ovarian cancer (OC) on microRNA (miRNA) targeting and alteration in target gene pool using our in house programming tool RNA hybrid. From this study we obtained two putative miRSNPs rs61764370_kRAS-hsa-miR-223-5p and rs2069414_CDK2-hsa-miR-183-5p having functional significance in ovarian tumorigeneseis. Further investigation and target validation will help us to achieve a deeper insight into unexplored variables of gene regulations linked to development and progression of OC.