Biotherapeutics Potential of Human Gut Microbes of Rourkela, Odisha Against Enteric Pathogens

Abstract

Biotherapeutics is a newer approach towards treatment of diseases using living organisms or their products. Probiotics as biotheraputic agents are now the main topic of research that is gaining attention of the scientific researchers around the globe. As the definition given by FAO/WHO probiotics can be defined as live microorganisms that when administrated in adequate amount confers a health benefit on the host. Probiotics when isolated from the human Gastro Intestinal Tract become more specific towards treatment of diseases related to human beings due to population specificity of the probiotics. These gut micro flora play an important role in maintenance of the gut health by conferring certain health benefits and preventing the invasion of the disease causing pathogens. Diseases such as salmonellosis, inflammatory bowel disease, colon cancer, infectious colitis and infection in urinogenital tract are the most common as well as life threatening diseases causing maximum death around the world. So treatment of these diseases can be done using biotherapeutic approaches including population specific gut microbiota as a replacement of traditional medicines and antibiotics. The project work mainly focuses on evaluation of the therapeutic and prophylactic activity of human isolates derived from Rourkela region, Odisha against enteric pathogens.