Designing Novel Lead Molecules for Human Coagulation Factor XIII B Involved in Cardiovascular Diseases

Abstract

The coagulation of blood is very important characteristics of the blood since it protects us from excess bleeding by forming clots and binding it. This is done by protein called fibrin stabilizing protein (XIIIB) and plays an important role in clot stabilization by crosslinking fibrin chains. However it has been found that these fibrin stabilizing factor also known as blood coagulation factor XIII is responsible for many cardiovascular diseases. But very little is known about the role of FXIII in vascular diseases. Although it showed increased levels of FXIII A-subunit antigen in patients with obliterative atherosclerosis of the lower limbs and in patients with diabetic angiopathy, small patient numbers make the interpretation of these data difficult. However, increased plasma concentration of cross-linked fibrin polymers in acute myocardial infarction has been described, assuming the presence of increased plasma FXIII plasma activity in patients with coronary artery disease. The research work aims to develop a novel lead molecule for coagulation factor XIIIB involved in cardiovascular diseases. The proposed work defines the protein structure, identifies the proposed ligands and develops the molecule by docking.