Genipin Crosslinked Gelatin-Guargum Based Phase Separated Hydrogel for Drug Delivery and Tissue Engineering Application

Abstract

The rising cost of development of new drug has made researchers to look for an alternative way. In recent years researchers have given a lot of importance to increase the effectiveness of the existing drugs. No other thing affects the potency of the drug as its drug delivery system does. A lot of research is being going on to develop a novel drug delivery system. A lot of research has been done on different combination of guar gum and other substances as a drug delivery system and most of them have been done in India. Not only does guar gum is being used in food items extensively, it is also thought to have medicinal properties and optimal properties to be a drug delivery system. Guam gum is abundantly and cheaply available; with 80% of total world production is from India. In this study we have researched the possibility of using Genipin cross linked Guar gum-Gelatin phase separated hydrogels. We have done MTT assay with MG-63 cells to check cell viability, drug release test with Metronidazole, and hemocompatibility with human blood to check bio compatibility.