Synthetic Approach to Coumarin Derivatives Through C-H Activation

Abstract

Coumarins are a family of naturally occurring compounds. Coumarin motifs are present in numerous natural products such as dicoumaral, querecetin, geiparvain etc. This class of compounds also exhibit promising biological properties such as anti-inflammatory and antipyretic, antioxidant, bronchodilator, vasodilator, antiameoebic, antibacterial and antifungal activities. Coumarins and their derivatives are also used in cosmetics, perfumery and polymer industries. These features have elicited increasing interest in exploring more and efficient methods for their synthesis. Several classical methods involving Perkin reaction, Wittig reaction, Pechmann, Reformatsky etc. have been developed for the successful synthesis of coumarin derivatives. The aim is the preparation of coumarin derivatives through C-H activation.