Comparative Study among Different Cryoprobe Configuration for Effective Necrosis of Biological Tissue

Abstract

The complete necrosis of malignant biological tissue can be achieved, when the optimal parameters (generation of ice ball around the cryoprobe, ablation ratio, cooling power requirement) are known to the cryosurgeon. In this study the optimal parameters(volume of ice ball around the cryoprobe, ablation ratio, cooling power requirements)are predicted and compared to maximize the tissue necrosis. Surgical parameters like lethal zone, frozen zone and ablation ratio are studied for different placements of cryoprobes. The percentage increase in ice ball volume (obtained at the end of freezing cycle, i.e. 10 min considering with and without central cryoprobe configurations) decreases with increase in the number of offset cryoprobe at same opereating conditions. It was observed that with the increase in offset cryoprobes, there was no remarkable growth on ablation ratio at the end of freezing process. However, the less number of offset cryoprobes resulted in effective ablation during the early stage of freezing process.Also, the cooling power requirement increases with increase in the number of offset cryoprobes and also increases with decrease in cryoprobe temperature.