Effect of Perfluorohexane Layer on Tissue Necrosis

Sharma, Sujeet (2017) Effect of Perfluorohexane Layer on Tissue Necrosis. MTech thesis.

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Cryosurgery is minimal invasive technique in the field of medical science for the ablation of tumours. A new concept is proposed to improve the efficiency of the cryosurgery. The experimental study has been done on tissue. There are so many research going on in the field of oncology and some techniques already exist in the system for the ablation of tumour and cancerous cells, these techniques include radiotherapy and chemotherapy. The main disadvantages of both the techniques are that both costly and harmful also (i.e. have some side effects). In cryosurgery harmful tissue which infected from any disease and become tumour can be ablated by decreasing the temperature of tumour at very low. Due to decrease in temperature the metabolic reactions of the tissues stop which results in death of tissue cells. There is no need to remove these dead cells by operation, the body itself will digests the dead cells. Human tissues do not work below -40℃, hence the favourable temperature in case of cryosurgery is below -40℃. As the temperature of tumour should maintain below -40℃, it will stop the metabolic reactions of cells and make them dead but the low temperature may also cause harmful effect to the surrounding healthy tissue. Now there are so many techniques present which could be used to get lower and lower temperature in cryosurgery, but this will have higher rate of possibility to destroy healthy tissue. Therefore it demands to develop a new approach technique which can ensure or increase the safety of the healthy tissue. The new concept, is introduced that contains a layer of lower thermal conductivity. It protects the healthier tissues at low temperature. In order to study this concept experiments have been done on the tissue. The experiments also have done without the layer and with the layer to compare the results for ensuring the reliability of the concept. The experiments also performed with varied insertion depth (ID) of the cryoprobe without and with the perfluorocarbon (PFC) layer. It is found that with increase in insertion depth (ID) lower the temperature and introduction of PFC layer results in more decrement in temperature and ensures the safety of healthy tissue presents beyond the PFC layer.

Item Type:Thesis (MTech)
Uncontrolled Keywords:Cryosurgery; insertion depth (ID); perfluorocarbon (PFC); cryoprobe; tissue; tissue ablation; tumour; thermocouple; ice ball
Subjects:Engineering and Technology > Mechanical Engineering > Cryogenics
Divisions: Engineering and Technology > Department of Mechanical Engineering
ID Code:9000
Deposited By:Mr. Kshirod Das
Deposited On:26 Apr 2018 16:52
Last Modified:26 Apr 2018 16:52
Supervisor(s):Subramanian, Anbarasu

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